Spontaneous recovery of the pituitary-gonad system after the use of testosterone preparations for hormone replacement therapy or male contraception occurs in months to 2 years. There are insufficient data on the timing of recovery of the pituitary gonad system after androgen anabolic steroid abuse. Users of testosterone preparations use post-cycle therapy to restore the pituitary-gonad system. Its effects are unknown and need to be studied.
To evaluate pituitary-gonadal recovery in male androgen anabolic steroid users against the background of refusal of administration and use of post-cycle therapy for 3 months.
After the end of testosterone cypionate, regardless of the total dose or cycle length, a post cycle treatment (PCT) plan should be developed. For most men, PCT is required after stopping anabolic steroids for more than 10 weeks, but can be skipped for shorter periods.
3-month discontinuation of androgen anabolic steroids in the context of post-cycle therapy restored the pituitary-gonad system in 79.5% of volunteers. A negative effect was found on the recovery of the pituitary-gonad system of the androgen anabolic steroid type, the duration and dose of use, and the number of drugs administered concomitantly. Inhibin B levels may serve as markers of spermatogenic epithelial repair.