Explanatory text


Spontaneous recovery of the pituitary-gonad system after the use of testosterone preparations for hormone replacement therapy or male contraception occurs in months to 2 years. There are insufficient data on the timing of recovery of the pituitary gonad system after androgen anabolic steroid abuse. Users of testosterone preparations use post-cycle therapy to restore the pituitary-gonad system. Its effects are unknown and need to be studied.

Explanatory text

Target


To evaluate pituitary-gonadal recovery in male androgen anabolic steroid users against the background of refusal of administration and use of post-cycle therapy for 3 months.

After the end of testosterone cypionate, regardless of the total dose or cycle length, a post cycle treatment (PCT) plan should be developed. For most men, PCT is required after stopping anabolic steroids for more than 10 weeks, but can be skipped for shorter periods.

Target

Conclusion


3-month discontinuation of androgen anabolic steroids in the context of post-cycle therapy restored the pituitary-gonad system in 79.5% of volunteers. A negative effect was found on the recovery of the pituitary-gonad system of the androgen anabolic steroid type, the duration and dose of use, and the number of drugs administered concomitantly. Inhibin B levels may serve as markers of spermatogenic epithelial repair.

Conclusion